                         ˿µϣ20060428գ

06.04.27ûи
06.04.28, ӡҿŵɴ
06.04.28, Ľ塶ѧܵıɽһǡѧ־
06.04.28, GaryڿƼڿͣ١
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06.04.28, ݿߵ

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                         ҿŵɴ

                             ӡ

    һֳΪŵnoni룬Ҳŵŵ桱
桱֭ıڹڰײֱͨķʽУ۸񲻷ƣ
һƿ500Ԫ˵ǴȻֲnoniʵɵģǡ԰
̫ƽྻȾĴϪأϣᣩȺģ
ع㷺Ϊҽгǧʷ

    ƣŵ֭ǿ壬ٲɰƣ֢
ʪؽס򲡡ʹ֢ͷۡβϵͳǴ֢
ϵͳڷʧǰٲۡͷָײѪѹνˡ
״ٲ̴ѪǴ̡ء֢Թ֢ܽ͡
̵ȵȡ 

    ŵʵʲôأһݿֲѧ
ΪMorinda citrifoliąΪϭ½ΪꪣΪͲڹ㶫
ȵصвҩͬһֲȻԹžͰŵҩã
ҪҶӻѹʵˣΪãĹʵɰ
ΰٲĿڷҩȡҩֻðĸҩҲĹʵ

    ŵ񻰵ĴһλˣڵΡϪŵʹ˾˺
ʵ򡤺ˣRalph Heinickeʿ˵ùմѧ
ѧʿѧλ19501986Ϊֲܹ˾Ȼо
޵øҽѧ;ƪڲ޵øѧġ

    ʹ롢ŵ洵Ϊġʢѧҡ
1985귢ڷѧԵ԰ڿ̫ƽȴ԰ͨϵһƪûо
׳ͨ¡ŵҩԳɷ֡ƪУƲ
øҪҽãҪһ·ֵ롣˰
ΪxeronineһֵĽԭproxeronineת
ģתתøproxeronaseƵġƣ
ŵ֭ԭתøмߵҽƼֵܹ
ƸѪѹʹؽסθŤˡˡ֢˥ϡ
Ӳ֢ʹּ

    Ҳ֣شķ֣Ϊʲôﻯѧҽѧרҵ
ѧ־Ϸȴһ԰ڿ͸¶µʵҲ
еİأҽѧݿԷ֣ûκй
ԭתøϡ֮ЩʶǺ˱˵
ҷ֣ûбκоظҲδѧĳϡ
ҲûйЩʵĻѧṹʽ

    Ȼ˵ȤѧҵЩ֡ר
һɶŵ֭ҵȳҲѸ𣬲Ҫǲȡ
ֱķʽŵƲһλؼҽѧʿ
Neil Solomon1993Ϊҽִ֮󣬳˸
ҽѧĹĴߣΡŵͨѶίԱᡱҽʦ׫дġŵ
ۡһŵ̵֭ġʥ

    ûκȷ֤ܹ֧йŵ֭湦ЧЩ
ʵŵܹ֭ưϸĶǳɷ֡Ĵѧڶ
ŵ֭Ƿпٴ飬ֻٴһ飬δн
ۡŵ֭еˮ֭һ֪п
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    ŵ֭мصĺǳߣЩҪͼʳǧҪ
ŵ֭Ѫع߻صഫ쳣
նɴѧоԱһһΪŵ
֭βطãѪعߡ

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ܹ֭β1998꣬4ݵļ쳤ŵ֭Ħִ﹫˾
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ͬһ꣬ʳƷΪߵĽǮƣֹŵ֭Ľ
ںۡ

    ŵɴǳҵĿıѧߺͲ˰װȥģ
Ӧð˺ǷĴҲӦñֹ

2006.4.23.

Ƽ2006.4.26

(XYS20060428)

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ѧܵıɽһǡѧ־

Ľ

쿴˿κȽڵ⣬Ҳ߱רҵ֪ʶ
Բۡһձʵϣʹҷ

ҵһڹרΪĿѧйѧ־ժ
ժķⷽṩҲ͸¶ΪֻҪ˵
Ҷ֪

ǵĸѾ10꣬޻̸ڹ䶯ǲ档һ
죬ҵĵط̸Ҹ˵˿濯ǵĴѧ
ʵΪܳԾƽҺΪ¶ʿʾ
ͬ顣ҺܾȣΪǸǳֱ͵ˣĻ

˵ҷʵֻǱɽһǣڴδҷ棬
ǲǺܵùʵǿϵͿѧ״µͨ˰
ͬǡ

ô֪ѧٺѧ˺ƽ˵̫ף˲
֪һͶһ֪ÿ춼ڷѧ־
ʶĸӣϸգֻ޸ݰڿܵ
£Ͳѡˣֶȫ¼ѧ־Ҳû취ˡ

ʱЩѧ־һרΪһѧУĳרҵ
򣬳ϼһ־ʮƪرͬ¶һ࣬Ҳˡ֪
ǲǻһʲٵĿоԷѳĶһ棬ǵǴؽ
⡣

˵Ȼרҵϲ˽ôǱϾʮˣĿ
ǰ־ѧˮ׼ֻܴҵĽǶȿƺûʲôرµĴ
ԽԽˡ

һһһѧڿα༭˵ģ
ҾŸӾӣЩѧ鹹ģȫ
ɾɾ֮󣬾ûʲôˡر¶ĳĳ֧
ģ־3ƪ¾ͿԽ⣬ȻʮоѾͿԽ
ˡְˣǻǵͣΪĹֻҪһֻ۱һ
ֻۣʵɵģѰաһܸͨʲôأ
Ҫ־棬ǻôأ

ҵõһۣǾǵѧ־ô졣

Ŀǰѧ־ľƺǹͬģ٣ѧ
־Ҫյģյľ취ǰհշѣһ800-1000Ԫ
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˵Ϊͨе־շѣʵҲ˵ùȥǾǣ
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ͣأңҵƲ⣬ĴѧȱǮѽάһ70ʷ
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Կզ£ٿˣ

αȽ֪ѧٺѧΪһý屨رǡ
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ˣ˼Σǰ̸ѧܶԹҼ¼ƻľ޴˺
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Ҳ֪ôģȺѧܣйزžô
ãѾãѣ¶ģûʲôϣģ⻹
ǽܲŰɣͨʵûʲô취ֻܹˡˣҶԷ
Ϊǳ˾ġҼӼ棬Ҿǳӣ
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дͲ߼ˣ»صּҵĽǣҪ
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ϵʽԣ£ϸѧ־Ҫͣõ־Ҫ
֧֡־¼Ҫֻѧܵһ
ģʵҲ벻ˡ

(XYS20060428)

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ڿƼڿͣ

Gary

ϤųǰѶӳš棬շΪҪĿķ
νѧְơµġڿƼغҵƼг
̳ڿͣ١

ѧվ˿ԡڿƼðѧ
ع֮2006412գߵʵй걨
10桰/㡱Ŀˡѧ족ҵܡһģӳ
ڿƼغҵƼг̳ڿշԼ塢ѧ
⡣¿ȫҪվԡרΪְѧλ
ѧܡΪתءһɹųڲе20061ڵ
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̸ΪΥйس涨ڿͣ
µġڿΥ֪ͨ顷

鱾ѾֵñǵǣǷ̫᣿ý
ͨǷ̫٣ܷסȫԽԽķసͷ

˽⣬ڿڵİ쿯˸Ͳҵˣǳаһ
ЩνġĻˡٵ׽ʡߵġһĻ
͸ûбҪһȾǵѧҪͷ
죬Զܷ硣

ǵ쵥λǷҲӦ̷˼һ£ԴҪһѵʶ
ʲôѧڿʲôѧҪһȷжϣΪҲ
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ѧ

ʵ֤ǵѧ硢ڿȫиҵһֻҪǵ
˽һܹסԽԽӵѧ
Ⱦͷ

2006-04-28

(XYS20060428)

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ŭ˲Խվ
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һ	ҵŭ

ŭˮ翪⣬Ϸз֮˺þãƺ
ţҰѰǰʼдıģϣŸڡ

۱˫ԻΪ㣬һɣΪɣһǷ
ɣΪαɣ˫ǹལǹò֡Ϊڵң
ˮмңûŭԿһͷˮֻù˵˵
ݡɣ20059¼ҵŭһˡȻŭȻⲻ
ҪҪʡҪ롣ʲôʲôʲôŭӵ⣬ŭ
׿ɲԽˮվȻˣˣˣǣҲմ֣˵һ
롣ȻҲмң˵ĿܶлΪŭ̫
Զȥһ˲סڿ̸̸У˾ûȥһλΰ˵
ûеûзȨұϾȥˣһϣȡ˷Ȩ
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˵۱⣬ǿֱ۵Ļ⣬εϿ
ɳٻǳרҵֱ۵ļ⣬˭࣬ߴߴ
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Ҿþ۱˫ûгԺ͵ļ󣬵ɵ
磬»ָ𡢵ѡڿ̵ܱһԲּ⣬
ץӡӡñҪһ򱶡ǻıȡõĲջ񣬱Ͼ
ϿӵʱѾΨһ۱磬ܹй
ϣйý϶ǹվչ
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ΪʲôҪŭأΪӦݵϽزμ
40䡣ŭԶˡҴΪд·衷
׼еӻйʱ򣬾Ǵŭݳɹŭģ
ҵȻҲ뵽⿴ҴϽ⣬гټʮ;
о¹ءΡɽҤҲ߹ĵص㡣

ŭˮأˮ֮Ǹأرǹɽء
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źһǵ˹ɽسǣûж߼ʮĶ۾ӵһ
Σǵû߲ԶƬ֮Ĺߡ

ŭϿٹࡣ뿪ǵڳ
ΡҪŭһٶ๫蹱ɽһ·ϣ
ɽԸ߶ȷǳԵظо𽥽ͣɽɶֱ𽥱滺ӹ
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֮ŭ˳İټʮ

ΪҴӳɶկẽϿߡȽϣ
ẽϿȱŭϿȣ֮׳۸߾Ҫѷһˡ

ŭĻ䱣

ŭˣĿһ룬ϡ֮أһɽˮ㡢
деĴȻԭʼۣϰַɣɽ
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ȿѵ״̬£1000׵ĸ߶ȷΧڣûʲôľ
ľҲټԭֲ̬ǣ蹱ɽϱӼ
ٹҲмʮϰٹߺεΪ5128ףǵṩ
֣ϵͼΪ4649ף˵ɽﻹгƬԭʼɭ֣ϡ
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нŭϣʱ̲ϣԽһһе׮ʵˣ
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1700ǧǾװԣ˽ӽϿˮվ1800ǧߣ
ҹƣΪŭˮԴԶ㣬ʵʷٵöࡣȥʱ
ѮϵĺˮͲ󣬵ǣЧȻǺܿɹ۵ġ

Ͻ˵ˮվ޽֮γһˮ⣬
ڴٽˮָ̬˻áˣŭͱ
µֲԣŭ޽ˮվŲƻԵغ֮
ʹ޽ԭԭ̬ҲԶָܻˡ

ŭ˲Խվ

֪ʶϲ䵱ȻҲǡȾڻ
ߣͲ߶ˡŭӣһƬҵı
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޽ˮվȻڹҵĴ£ǿ˵ȫǹ
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ҾãŭߵЩũ񣬼ҵѾöһУ΢е
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Ļȵԭ򣬰ǨԽԶǵӦԽ͡

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ˮҲûκЭصġϤЩ
ȻԹе1%ǿƲǨ

ˮĽܺܺãʹǸܵؿ⡣ǵһǵũ
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ǵĿ̶һЩƴֵǿƼţڹʱŹȨ
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ʱ˽ʱȱ֮ûȨũҲû
˺طּۻ۵ȨΨһĹġм价ϵ
̰۽Ѿ˳鳣ڻˡ

ڶǵũûũ֧֯ίܹΪũĴ
𣿴֧ǡίִܹũͿ̸

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ˮڹص㣬벻ͶԶˮվϵ˼ʶ
ڵˮվ޽ƹʡƫĵɽũ
һеĵԡԭе׼Ϊ׼ڰ


⣬һλ⡣ľ廯ϸΪ롢ʡݡ
ءǸвͬݶλ涨λǼȿܴҡ
͹ҵĿ̽湲ͬ壬Ҳܴũ񣬳ΪũĴߡ
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ѱ֤ũóֵ汣ϡʵϹ̽Ⱥڵ棬ı໥֮
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˵ŭˮվǲðɰŵİ취վռũأ
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ˮ˵ǿ棬ڹҵˮԴɾ۱裬ˮ
ڹص㣬벻ͶԶˮվϵ˼ʶҲǲ
ݵġ⻰˵þַũ档
ĿǰйЩ׳ũ񣬿ܶͶԶ
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ӳԶŭũ񣬹ؼǵ
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ΪʹĴгƻũ񲻵ƾٴ
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˼ǣ⻧ũſһĴϷë
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ڳϣοǽϵĴɨä

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Էθź֮ɣý磬ͨҵʵ
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رũϵģǵصƶũĶӣũ
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Եطŵĳϡ

Һ룺78ǰë壬򾮸ɽЩũ񣬻
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ЩˮȨҵҡԱǣЩƶƵľ
жٱ֮ģ

Щӡ족ĹٷţǷþѻƬЩ
ũ񣬶Լأ

ˮվܹʹŭϵˮ߳Ӱһ
Сŭũܹ˿첽ũ

2005/122006/4ɽѧУ

(XYS20060428)

˿(www.xys.org)(xys.dxiong.com)(xys.3322.org)(xys.xlogit.com)

йκ׷٣һ֮Դ

ߣkaminari

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κȫԺʿĴ׹˿̳Ϊ˻˺ܴƪ
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ҽѧʿ֤ʱƽ˵˰ҵ־Ըع̤̤ʵʵ
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1996 18գκȫɹйҽѧѧԺ
ҽԺ9λרɵ󣬷ΪƼ
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κȫ㽶ĳУĴмҲĴźҪһ
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111գκȫɻ5صĵλҽƴѧһҽԺϣ
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˵ƲҵĴ̼󣬡ܹԵĺӣʹĸ׻У׳
ҵǰСĸϸĲҴ𲻳λڼȱ˵
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1983꣬ϲѧоҪ֢һ롣
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ҵʱ˶ʿġСĸϸ̥ϸԱо㡣

ҵϣͬѧԤԣɴߣκҲ

ҽƴѧһҽԺ̺ʦκȫٴʵڷḻ
֢߸Ĵ̼Ҳڲƣκȫƽÿȷ20˻֢֮
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ҳ򣬶֢ҩסЩɰС

1987 1988꣬κȫ΢¹۲조Сĸϸ2۲죬
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Ľۡ1989꣬лѧ־ġСĸϸĳ
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ΪйˣҺԺκȫ˵ĵһ
ҪȥҪһ豸Ϊ˿ʱȫϵ
ͳѡձעԭˣ滹һѧѧ101ı
κȫӮûᣬѧ19914£ھѧҽѧԺо
ġκȫʿ⡰֢Ƽоо

ҵԿ

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豸ǰ绢ձĻ豸κȫֱʵ˵
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ձԸ఩֢˵ܰϸɱϸвⶨ
5-80%֢Ѫܰϸϸֳɱ˻ԣ֮Ϊ
ϸɱˣAntologous Tumor KillingATKԡ׷ٵ鷢֣
ATKͬٴԤءATKԵķΰߣ80%5޸
תƣATK Ի2֮ڸתƣ5ȫͽ⿪ͬǰ֢
ߴʱ䳤֮ա

ATKߣκȫǰյATKԵķ
ٴԸơ⣬ATKѡӦڼڻ⼤
ܰϸȻڣ˷ӳڰ֢

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ܰϸʾܰϸɱϸӡ
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κȫ˳ձδÿĳʵʱκ
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ԺκȫɵƯձ۷ˡһ꣬ί
κȫǰʵϰרѧߣĿǣǷʱҴ
࡭κȫһߴ߼ѧһ߼оڷڹڡ6ʱ
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˵Ĺǵġ˵ܺ͡һΣεڹ̨ԡκ
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19955£ҵйפ¹ݽң뵥ҫ°һ
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1995 1120գ¹ݽѡΪѧɼѧԱ
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20ʱѧԱ̸Ҫ˲ţӱЧʹӻж


18غ弰ֵ֮ĳӣ죬Я޴Ůװعϼ
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֢ǲп磬˰ܵǲп

1996111գκȫԭλƵ֪19952λڱΰɡ
1987ʰлĺνڣ3λڽΪо֢רҡ£
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ҽԺԺһ֣߰ڣһκȫţһ죬˰
ļǿܡҽԺѴӦ䡰˫·Ҫ󣬲500Ԫ
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1996320գʱڣκȫӵĸУϼΪڵľס
װ޿Ϣκȫŵ绰һʱŮͷؼҺ
úѧġ

1996 330գκȫϼ20Ԫ豸ԪԼϸ
꣬75ĸӡϻع30öϸԹܴڽƤһ
ƵĲϡκȫӵİ֢磺ӵһ㡱Ҳ
Щƹ罫ǴรӤ

֢ĩж೤κȫƻ5ʱѳɹƳҩٴƺ
飬ӳߵҪʵʩоƻ731СĿȻ
10ʱ䣬ͳΰָϸȾǰĸ


̤̤ʵʵжκȫᶨҳʵɡڹڣû
ľ񸺵ҽĿȫԸɻϣκȫѷɽ
Ů(ע˴ʡ˱ֽе֣Ϊǵδ)˵
󣬺úѧϰҵоûдﵽĿ꣬ͽȥ

(XYS20060428)

˿(www.xys.org)(xys.dxiong.com)(xys.3322.org)(xys.xlogit.com)

йκѧо1994꡶ձš֮

ߣ

κȫԺʿĶƪ̧ﶼᵽձڼгɹ
ıձҽѧ̳űκȫоɹ
󣬡йҽѧ̳Ҳ˱NHKκȫ5£Ƴ1Сʱ
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ѧšƽ8꣨1996415գNHKר⡡ [a뤬ίؤ?
ha߯aԥǤ򹥓]953£ǰ׷
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13濯һƪѧʿоİо£ĿΪ[󼚰
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ģ
--------------------
ձš19941119ճ13

ѧ

ʹantisenseRNAʹϸԼ

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롣


------------------
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(XYS20060428)

˿(www.xys.org)(xys.dxiong.com)(xys.3322.org)(xys.xlogit.com)

ŷشĴѧĵ

425սŷʵ¼

[»]:Ἰ⣬415պ17գĴѧŷᣬ
κȫСһµĵͨ,ֹڶ
֧֣ͨΪΪԴۣǷμ
صĵ鹤  [16:07] 

[]:ǳѧΧѧĽ衣ڽͽ
һǿⷽĽҷйصϢ漰Ĵѧй
Ҳý˽⵽ⷽ飬ҲṩйصĲţĿǰв
ۡлл  [16:08] 

[ձ]:ĴѧĵڱֳɣҲģ
ǲǱУ֯רԱУѧ淶е飬
⣿ĻܲŻ᲻̨һЩȽϹ淶İ취
˵УУġѧȦ棬ʦ֮ĹϵҲǧ˿Ƶġ
۵ĻرܣôƣǳҪ֪Ƿǣ  
[16:09] 

[ձ]:ڶ⣬йر츢ĸѧʧǳ죬
Ϊϴѧ㣬һŸƾ򹤡ǲǽѵ
֣Ϊдĸãлл  [16:09] 

[]:ܺãҸ˵Ĺ۵㣬Ϊϵѧ
罨Ļƣ֯򣬹ʾƶȣѧ罨Ļƣ
˵϶ǷٵĻƣӦһǳЧǳ壬ҲӦŬ
Ĺ룬ӦŬ  [16:10] 

[]:˵ĵڶ⣬첿ѧ߿Ҳ
һЩýϿˣʲôԭ򻹲֪Щѧ߿ǿǵԼ
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κȫµļѧΪʦҲ֮Сǲ
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ϰ߳Ȼ˵Ҳ󵼴ҵġǰκԺʿ·ݵĹٷ


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һӢChinese Journal of Cancerѵ֢ѧϾ

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3.Kawasaki,H.;Taira,K.Nature 2003 Jun 19; 423(6942):838-842.
7.kawasaki,H.;Suyama,E.;Iyo,M.;Taira,K.Nucleic Acids Res. 2003 Feb 1;31(3),981-987.
8.kawasaki,H.;Onuki,R.;Suyama,E.;Taira,K. Nat Biotechnol. 2002 Apr 20(4):376-380.
12.Kawasaki,H.;Taira,K.Nature 2004 Sep 9;431(7005):211-217


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𣬻Ǹԭϰڴ򹤣ƲѧˣҲûʸΪʿ
˶ʿʽʦʺAssociate ProfessorǴࣩ

Tenure-track ProfessorTenured professorһѶȣѶȴ
СһѧУѧˮƽ졣ԽǺõĴѧԽѣѧλĴѧ
쵽tenureʱϲĴѧΪû߽ѧ̫طסˡ
һ㣬Tenured professor Tenure-track Professor֮ҪԶԶС
Tenure-track ProfessorNon-tenure-track professor֮Ĳ

һЩõNon-tenure-track professor˻ع
ѧνڵıȡְλԴTenure-track
ȻеƽϣǿTenure-trackʾʹδιʽڵ
Non-tenure-trackǵı

ܵĽͣڸͬ´ĲдTenure-track
ڣڶԴվнɡڡȻ󵼴֮ӣ
̫лղСԸΪ˼ǿ
ԼNon-tenure-trackĲͬΪ

(XYS20060428)

˿(www.xys.org)(xys.dxiong.com)(xys.3322.org)(xys.xlogit.com)

ͬõĴ

raowu

ҵͬôѧ鷳ʵԽԽ.

"ԺԺ¼",Ҳ˵ó.

һѧ,ȻѽʦĸλƴӢķʱͳ˴,ҵ
һͬôѧԺʿ,,,ĸ㲻ػӢĸ㲻?

ĸ㲻,Բֵ,Ӣĸ㲻,,ʷӰ.

ʲô?ֵ䲻,˲˼,,Ŀѧʲô,ֵȥ.

(XYS20060428)

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ձ񻧴ѧڱ

룺Dr. Ye

 2006/4/27

2004꣬񻧴ѧѧĴǰ(59)йʹʯߵר
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ĸ淢˵飬ǰڳûнʵʵ񻧴ѧҪ
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ѧǰιƽѧЯĸñ֮ǰġЯġ


ѧָڳרһش⣬о
ʮźǽݵķ롱

 2006/4/28

񻧴ѧĴǰ(59) רмؼܿʵݵ⣬
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ǰǰרԼǷеķ롣
Я챾ɽУָУ׼о߻淶
ίԱ֮УרнδʵʩΪʵʩһ
¸еʮźδйشѧԼϵ֮ˣش
Ҫĵ

(XYS20060428)

˿(www.xys.org)(xys.dxiong.com)(xys.3322.org)(xys.xlogit.com)

̩˹˾Ĵѧ빫С¼鱨Ĺ

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СĿķһѹרתãҲǹ
ڹʡȻ־ģ漰һܣҲĴѧν
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Ĵ̩˿ع޹˾
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(XYS20060428)

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Ĵѧйѧܵѧָ

ѧ2006.4.28
ߣHao Xin
룺Yush

оĸСΪضĵķֲڲ֮
ڵŷϣйɶĴѧѧУרĵ
飬С조ѧ١ָز

Ȼ۲ܺܿƽϢԱָصĹ˾ָ𱾴
ȱ͹ۡ͸ȡйԼ顣
ѧӡʱвӦ

2003 ꣬ĴѧҽԺѧС17λͬڡ
Ȼ＼һ־쿹ԵĹ̶ġйý彫ֵ
ʣpheromonicinơPh-SAΪصشͻơķǰ
˸öļ췽йרĴ̩˿ع޹˾ͬ⸶
ҽԺ25ԪɷѣԤһ룬˳ɶƼֹ˾
Ĵ̩˾δɹʼרЧԣܾ֧һ
ɷѡһĴ̩뻪ҽԺ䱬Ϊթָء

2003ĵ6λȥ12дŸȻ＼
pheromonicinǡضϸáҪгǵ֡
ָأλ߷̰ѧ2 17յ937ҳ
Ĵѧŷߡѧ6λ߼ֲ߲Ϊش
Ȼ＼˵еʵ飬ǵͬʱе
ϡ4λĴ̩˹ԱǱɵʵ
pheromonicinﰲȫоλĴعҵое
pheromonicinԵķ

ΪӦѧ˵ָأĴѧ΢ѧﻯѧͷ
ѧרɵר飬ʵ飬֤١ָǷŹ
רС龭3µĹ֣١ûƾʵݡѧУԱǾܾ
ṩרԱܾһۡ

Ĵ̩˲ΪһУ˾ҪĴѧ鱨ȫġ
˵ûеõȨ˵¡רСĵ
ϡʲôᴦвŵ˹֥ӸѧFeinberg
ҽѧԺѧ˵йӦٷƺ͹ѧ
˵ָء

һѾˡȻ＼ĵڶͨѶߡ
ѧĵGeoge WuJames Walter˵ѧ˵ί
Ա֣ᷢûпɿ֤ݡֲָ֧أˡûне顱Ȼ
＼Ҳڸ˸¼Ĵѧѵתÿ
Ĵѧ˵ǽЩɡֲʧˡ
С죬˵ԸѧҵӦãʵҲҴ
ĵط

Science 28 April 2006
Vol. 312. no. 5773, p. 511

University Clears Chinese Biophysicist of Misconduct
Hao Xin

(XYS20060428)

˿(www.xys.org)(xys.dxiong.com)(xys.3322.org)(xys.xlogit.com)

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(XYS20060428)

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ԭĺҾֻעΪĳʫûעϹŽǵ伮
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İҶԡԴ˵ǡ֤Դ˻Ϊָ
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֪ѧĴϵУڴƷַΪ
һʵʷʵķ򡢷
ʵĻϣ˼Ĳ۵磻Ӧ·
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⹥ҡǸϮԴ˵Ĳ
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治룬һһȥʹϵѧƵ
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ԱעܼȡԭʼȵҪ¡

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롰೭ϮָʵأʷӦ֮

һʹŴѧʷǵʱѳһ걸ר
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缯еءϵͳԮϡȷ˵гһձд
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Ļ۵ˣ˭дʮԵ֣һҳ磬ҳһ
ֻϮԴдԣʵ̧̫ٱˣʵ
һҹҳΪʵѧΪ׳գ

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ֻԼĹ۵㣬ұ˲Ϊͨ

ϲáɽʰáλߵİ䳰ȷʵ
ɲءʶǣһƪֻ߱˵Ĺ۵㣬һᣬ
֮δδͬ⣬ҲΪ˳иϵΡ
磬һλ˵ҡ֮֮ͨ࣬ɲΪ˶
𣬾ͺñ˵ѧšҶϲһʵϣ
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ϵϵΣԾӸ֮ƣָʹҸұ𣿡
ĿͷҲֻһЦ֮һʡΪΪȷʵѧֱ
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ϣѧϻһӷ緶ڿΪʱ硣Ȼ˵
񣬲̫ƽϡΪ˵δؾȻȻ˵ʱһ㻹⣬
ٲҪ񡱵˺˵˵εĵزҪҪǫǫӡ
һ

ߡϵػӭƽضԡɽʰáѧ

ɽʰáҴӿѧƵĽǶоĻһγԣܶ
оŴкĻͬһϣԸӡҴû˵
ȱȱȶ֮Ķࡣĵڴѧ߶Ա
ǵѧϵ

ˡԡѧܡ֮Ҽ

ɣѧŸ󣬱ԡǣҲ
šѧܡţһ֮˽ˮ㡣ʷϣÿһ
һôˣŲɸ˵Ŀģӹţװ
磬ԡΨҶ͡й١ļƣ˶ϸ٣һ㣬
࣬ȡʱرڽ죬ĻŹȥ30꣬ĸʱ
˻ڣ˼άʽϰ߻ǱĬرšʷľֵע⣡

(XYS20060428)

˿(www.xys.org)(xys.dxiong.com)(xys.3322.org)(xys.xlogit.com)



ãǱɽҽԺҽƺƣԭλΪҽ
Ժƣ

ڹƶѧٻ˷ǳԾ
ѧѧܺ͸䣬ڵѧоˮƽоصá

ʵϣѧ֮ӷڹڣҲż
ʣ

Ŀǰ׼ϡϸֲԼٴ
Ĺ۲оһ֮һJames GuestλǼ
е߸ױǴѧ񾭿ƺͼоģʵĹλ
MiamiѧǵٴоɹûеõǺǻ
ͬ£˽Spinal Cord־ϷǵĲ棨Ľ
ǵƶȫԼ˻п϶ٴЧ

ѾSpinal Cord־༭James GuestѧУѧίԱ
ίԱᡢԼλ缶֪רҷţԭ󣩣ϣ
֮ʿ˽Ⲣ¶James GuestѧΪͽѧ
С

Ϊ缶ѧӢۣɷǵĿٻṩĽ飬
ڴ֧֣

㣬Bruce H. DobkinJames Guest׫
νϸֲԼٴĹ۲о
˿06.03.30)һжദʵ̰ĿǰҲڻ
йߵĸ׼

һоɹˣƷѧ
кγſԣ˷߿ǣ׽ڼΪѧߺԷΪߵˡ
пܿɷǷSpinal Cord־༭˿վȫĹ
лл

ף

ã

ƺ

ɽҽԺ߱п
ʯɽɽ͹ؽо

2006-4-26


ԭ

Letter to the Editors Re: Guest et al, Spinal Cord 2006, 44(3):135-42

To the Editors:

J Guest and colleagues reported rapid recovery of segmental 
neurological function in a tetraplegic patient following 
transplantation of fetal olfactory bulb-derived cells in the 2006 
issue of Spinal Cord (1).  Inconsistently, they then denied similar 
neurological changes in a recent report documenting the results of 
seven patients (2).

As the neurosurgeon who designed the clinical protocol and performed 
the transplantation series in Beijing (3), I am writing to offer my 
perspective on this case report.

Unethical International Collaboration:

Guest and colleagues rightly point out the need for objective data, 
but their case report raise questions about the standards for 
international scientific cooperation.  Sadly, their conduct has proven 
deeply disappointing.  Guest and Qian initially approached me in 
Beijing, offering to collaborate on a joint effort to evaluate the 
results of the OEG transplantation.  After I provided them with access 
to patient data and materials related to the transplantation procedure, 
they stole this material and published their case report without 
giving me due credit.  They also failed to obtain permission from me 
or my hospital to publish these results. Most egregiously, they failed 
to obtain written informed consent to participate in our study from 
the patient whom they evaluated.

The unprofessional and even unethical open stealing behavior of Guest 
and his colleagues at the University of Miami should be excoriated by 
the scientific community.  The international nature of my 
transplantation protocol does not give Guest and colleagues the 
license to neglect ethical and scientific standards in conducting 
their research.

Faulty Immunostaining Technique:

On a more technical level, Guest and colleagues were unable to 
establish whether the cells in question were OEGs.  I believe this is 
a problem with their own faulty immunostaining technique, and not a 
problem with our cells.  OEGs can be definitively identified by 
testing for GFAP and p75 (LNGFR) antibodies (4).  But as Guest points 
out in his article, he was unable to use the p75 OEG-specific marker 
because of the method he used to fix the cells for transport to Miami. 
 The logical next step should have been to re-do the cellular analysis 
with properly fixed cell samples.  Instead, Guest and colleagues 
practiced bad science by publishing their inconclusive results without 
further analysis.  They chose to cast doubt on the identity of the 
cells rather than their own faulty technique.

In collaboration with Dr. Wise Young at Rutgers University, my 
laboratory has successfully applied the GFAP and p75 (LNGFR) markers 
to dozens of olfactory bulb cell cultures we are transplanting and 
established that they are indeed OEGs.

We anticipate continuing our collaborative efforts with honest and 
respected neuroscientists around the world, and hope for a more 
balanced relationship in the future.  We encourage the editors of 
Spinal Cord and other leading clinical journals to hold their 
contributors to higher standards of scientific collaboration and 
ethical conduct.

I believe that honest and respected neuroscientists around the world 
will despise Guest and colleagues' stealing and dishonest behavior. 
Furthermore, I believe that Guest and colleagues should issue a formal 
printed apology in your Journal to me, my hospital, my patient, your 
Journal and even all the scientific community for their immoral 
conduct to hurt all of us.

Sincerely,

Dr. HUANG, Hongyun M.D. & Ph.D.

Chairman and Professor

Beijing Xishan Institute for Neuroregeneration and Functional Recovery 
in Shijingshan District, Beijing, 100041, China

Neurological Disorder Research and Treatment Center & Department of 
Neurosurgery

Beijing Xishan Hospital, Shijingshan District, Beijing, 100041, China

Phone: 86-10-88965507 Fax: 86-10-51625950

Email: hongyun@mailcity.com

Website: www.nrrfr.com

References

1. Guest, J., Herrera LP, Qian T.  2006.  Case Report: Rapid recovery 
of segmental neurological function in a tetraplegic patient following 
transplantation of fetal olfactory bulb-derived cells. Spinal Cord. 
2006;44(3):135-42.

2. Dobkin, BH, A Curt, J Guest.  2006.  Cellular Transplants in China: 
Observational Study from the Largest Human Experiment in Chronic 
Spinal Cord Injury.  Neurorehabil Neural repair 2006, 20:5-13.

3. Huang HY, Chen L, Wang HM, et al. 2003.  Influence of patients' age 
on functional recovery after transplantation of olfactory ensheathing 
cells into injured spinal cord injury. Chin Med J. 2003; 
116(10):1488-1491

4. Ramon-Cueto A, Avila J 1998.  Olfactory ensheathing glia: 
properties and function. Brain Res Bull. 1998;46(3):175-87.

(XYS20060428)

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