                         ˿µϣ20060420գ

06.04.19ûи
06.04.20, Ԥ棺212㷽Ƽ̸̳ѧ⣬˾
06.04.20, ӡԺʿָӦô
06.04.20, ӡпԺԺʿκȫȱеĻʶ
06.04.20, ֮ѧˣȻѧ뵽ѧ
06.04.20, ʤȡÿѧʿ˵滰
06.04.20, Ԫ¼ʼĩ
06.04.20, κȫĴѧŷϴʵ¼
06.04.20, ĩɷ˾κȫ˾VSκȫ˭˵ѣ
06.04.20, ̱Ժʿٺȱ
06.04.20, й걨ȱϯѧ
06.04.20, ˾ҶκȫظĻظ
06.04.20, СĴѧָ¹Ϊ
06.04.20, bystanderĴѧڡС¼ЦԷǵ
06.04.20, һҵʿĴѧĵȫûпԡ
06.04.20, ˭Ӧö˷йԱıʱ为𣿡
06.04.20, κȫԺʿµĲȫ
06.04.20, Ҳ̸СѪָ⡷
06.04.20, ϸκȫں˾ڵӡͼƬ˵ʲô
06.04.20, ŮʿҲ̸˾ˡ
06.04.20, ϺڲΡκԺʿҽʸ𣿡
06.04.20, ҩҵ˾Сαҩѧ֤棨֮

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Ԥ棺212㷽Ƽ̸̳ѧ⣬˾

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                        ԺʿָӦô

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    326ͨѧѧ뼼ѧԺ˾˿վ
κȫԺʿйѧԺĹšʵĴѧ
УйѧԺԺʿκȫƪģۣ
רҵרҵʿ˽ȥ412գ걨µġ
ȱ£ⳡý塣ڶ죬ձҲƪ
߶һ¼ĵ飬κȫġԾ֡ʣͬʱ
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۷Ƿ⣬ǲҵרҵⷽҲۡǣ˾
ڵɣʹϸκԺʿļƪģЩõʵ鼼ִѧ
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ǣǿ϶ҪԼԺʿģο漰ԺʿԼУ쵼У
µ֣£ӦпԺ֯רҽжĵ飬
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Ÿŷ

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顢Ҫ׵ö࣬һ漰ѧλȽϸߵģԺʿһģ
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Ӭϻĩõ̬ȣҲǷǳģھѧҪ
ѧ٣ӦصѧλȽϸߵˣѧӦԼǿΪ

2006.4.16.

Ƽ2006.4.19

(XYS20060420)

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                     пԺԺʿκȫȱеĻʶ

                                 ӡ

    ˡĩκȫĲɷã̿Цκȫ
Ϊξܾԭʼݣ

ܣԸԸ⹫ʵԭʼݺϣ
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ܹ𣿾ǵҲҪҪĳҲ뿪һר
֤ԭûκ֤֣˵٣㲻ÿЦ˵Ҫ
ԭʼҲ٣ԭʼ

    ԭʼݲܹΪǹһܣҲû˸Щݹ
ġκȫоѵҲǹһܣǹһܣô
õʿϷģģͱᵽʵ
Ժȫе˹ģǻܣʵйصȫԭʼ
ݾͶǿԹģרʱǿʾ֤Լġ
ԭʼݿԡѧܡΪɲôľͿ
Ļᱻ֤ʵ١

    ζԻ֤йѧԺԺʿеĻʶ߱Ҳ
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ΪԼ绤Ƽȥſƽ̳Ϥ˿Ѷ֪
ǳƭ̳ƭӰУǶԱ˿¶ļÿһѧ
ƭӣҪҥˡΪ֮绤ģҲÿ춼á
ҡκȫƳƭ̳ƭӰУҲ֤ǳǰ
˿¶ЩѧƭΪ顣

(XYS20060420)

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ѧˣȻѧ뵽ѧ

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ʮ˻ϵķԣ

꣬ȻѧһӣǺǴѧ
Ȩġѧ־ϵһƪı¶ʵϺм١˰Ѿ
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һƭ֣ƭ֣޳³ԺʿһѧΪα۸
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Ϊ޳³Ժʿķ෨ڡαѧα칤ð
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µʱڣǸѾʧȥ壬Ϊ
ѧѧίԱֻˣѾʮˣû
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ͿؽʹѧΪģ

(XYS20060420)

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ÿѧʿ˵滰
    2006419ˡѧᡱֻ̳ϵķ

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1Ҫһÿѧʿ˵滰˵ʵ˵ֱỷ

Ϊһѧߣ30ܵĸǣѧ֪ʶͿѧռԶ
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ᣬٽȻѧѧרίԱ顣

1  ϣѧᡱܶھٰۻᣬѧý
ʿṩ໥ͬ۵Ļ᣻

2  ܷרΪýʿٰѧ֪ʶѧαѧʷʶ
ѵࣿ

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57:50-6; Shrayer , D., Int J Cancer.1993; 53: 696-702; Scappaticci, FA., 
et al. Vaccine,2003; 2667C2677; Roberts, WK., et al, Blood, 2002; 
99:3748-3755ȣرǽԶʵĹԿȡ
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Nadler, R., Clin Exp Immunol. 2003: 131:206-16⼸ԭ
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2006-4-18

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ʵǵĻκԭģPNAS  September 25, 2001  vol. 98  no. 
20  11545C11550ݶһԭģIn addition, 
hepatotoxicity was assessed once monthly for 14 months by the 
measurement of plasma alanine aminotransferase, aspartate 
aminotransferase, and direct bilirubin. At the same time, renal damage 
was assessed by measuring plasma urea nitrogen and creatinine. No 
abnormal changes were indicated by these biochemical analyses (data 
not shown)κһ5ָ꣬ȷ˵10 mice in each 
groupĸԴʹ˳ؼ⡣

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κȫں˾ڵӡͼƬ˵ʲô

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˾ġκȫԺʿйѧԺĹš
УἰκȫNATUREMEDICINEĵʣݴΪκȫѧ
١֮һǣ6.߸Western blotting Ϊ
ֵף220KDVEGFRII͵130KD alphaV integrin
ӦҪԭףȻͼ7ʾĵУ130KDֻһ
෴30KDλȴһʮԵ֪˾
ǲǡκȫΪ220KDVEGFRII͵130KD alphaV integrin
߷ӦҪԭףôWestern Botting Ϊʲôһ
Ե30KDءʲô˼Western blotting
NATUREMEDICINEרҽܷ˾Լ룬
ʶ̫ᷨרҵջҲļ

˾ڣ Ϊͼ7ABWestern Blotting (W/B)
УһʾƲߵС
ܹ220KD  130KDWsetern Blotting ʵзӦ
ǲ200KD VEGFRII130KDalphaV integrinԼ
õ򵰰ǲǿVEGFRIIalphaV integrin 򵰰ף
W/B û,ҲܸȷĴ𰸡ʵ鼰ͼ7C˵ġʵ
κȫصʵУֻ˵áNATUREMEDICINE
Ųܷĳ̶ȡҲǣΪʲô˾Ϊ
õ򵰰׾ͲWestern blotting ʾԵͬ
˾ʲô֤Western blottingʾ򵰰
ûأ

˾ӦѵҪʾӡͼƬ˾ڵW/B
ʾƤϸСѪ塱ڡƤϸ
PAGEWBʱֻ֤Ƕȣ߹кʵеĲ
ϣϵͳͶĸǴڵģٻӰյʵ
˾ӡͼƬ˵ʲô⡣˵Ĵ࣬
ʵģ֮ͲʵκȫW/BӰʱ䳤һ㣬ʾĴ
һ㣬߻һֻС򵰰ףⲻʲô°ɣʾ
ǲǾΪûأ˾ڵW/Bֻ˵Ѫ
庬пƤϸֵ׵Ŀ塣֤κȫW/Bʵ
ġ

˾ںʹҿ⣺

1Ѫ򵰰׵ĽӦһ򵰰ڴ
ڶʧW/Bټ𣿺οW/BԴĶٺϸ׼
ʹ򵰰Լйء˾W/Bһϸ
ףһϡѪ壬ҲõһֻʾģӡͼƬ
ԡ˾ûпǵֻʾ£Ȼܿ
130KD 220KD Ĵо߲Ǹʾ㣬Ҫ
ĵʱѡ

2˾ڵѪȡ򵰰Western Blotting 
ûпܻúκȫƵĽأ

3˾֤ܲѪûпVEGFRIIalphaV 
integrin 򵰰أ˾ڵΪʲô/
VEGFRII/alphaV integrin ΪأȻʹ˾ڵѪ
ûпVEGFRIIalphaV integrin 򵰰ףԽܷԽ
Ȼ˵κȫ򵰰ﲻ򵰰ס

4˾ڵѪҲпVEGFRIIalphaV 
integrin 򵰰ףô˾ڵӡͼƬǲ֤ʵ֧
κȫӡͼƬأ

˾ڵӡͼƬûṩκ֤ݱκȫӡͼƬ
ٵġ

	4-19-06

(XYS20060420)

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Ҳ̸˾

Ůʿ

йκԺʿѧӣҲΪ˾˵乫
1Һ˾ڷ׷ǹʣҲ˾ڵѧֻй
ƽƽĽǸ·ģ2дӶұûκκô

ԣйκԺʿζԼ˸Ӵﲻŵ
ѧԷصɫСԸ˾ڣ䷳εŰ
áĴע飬ⲻΪԼعչ˺ܺõ
ҲΪԺʿѡӮ˲֡ΪκԺʿʮ֡෴˾
Ǹصӣʵʵ˵ԣѧģŶ
ٶԹͷҼʶ˾ֵĲʿĴ磬ΪҲΪĲ
ʿһѺйĲʿǰҪŰݷôίԱͨϵ
顣֪κԺʿġ˾ڰ칫ҪĲʿսս
˾Ҳӣᵹˮ裬ǹֱ룬
ذƷָǸ浽ʱ
˾Ҳؾᣬһ֪ʶǴѧƵĽ̲д
ġҺյǣĲʿЩⶼش˽
ҳ룬˾˺޷òʿףѧλǴҪģѧ
ҪģȻβ˳ǰѺ˽ﾯˣ̨Ϸ
һԺˡκԺʿҲ150룬Ȼ
©ܷnature medicineϣҲеˮƽȾ㣬
ǮҲ㣬²ΪϧκԺʿû顣ǱԼġʤ
ͷԡ˾ϵ֣һ棬˾ȷʵڱַ
һȴΪԼˣıҵδҵĲʿ곤Ĳʿ
ʦмʶ˾ڵϬԶԶˡҺΪ˾󺹣֪
ôͬУΪԼӮȡоѡ

Σ˵£ε˱ѧˣ˾ʼֻо
е©ϣõ𰸡ѧִ⣬˾ڼʮ֣оݣû
бС෴κԺʿȴش⣬Ǵϵ˴ϵ
æµƵƵãӿѧҵĽǶȿҲǸųб
۸ı죬ȴһһԣǰǼȥκԺ
ʿӦÿȥʮ֣ΪûΪѧվشʣٿȥʮ֣Ϊ
򣬻

йĴѧھȱ˾СԸƫΪƫˡ
Ȼڹ⣬ǲ͸¶ԼˣҲͬѡ
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